There are 17 words hidden in the letters of ISSUES, from 5 two-letter words up to ISSUES (6 letters). For points, ISSUES is best at 6.
No other single word uses all 6 letters of ISSUES. ISSUES has 6 letters: 3 vowels and 3 consonants, worth 6 points before any board bonuses.
6-letter words 1
5-letter words 2
issue5sises5
4-letter words 4
seis4sues4suss4uses4
3-letter words 5
ess3sei3sis3sue3use3
2-letter words 5
es2is2si2ss2us2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.