The letters in MYSTERIES make 262 words of two letters or more. The longest is MYSTERIES at 9 letters, and the highest-scoring is MYSTERIES at 14 points.
No other single word uses all 9 letters of MYSTERIES. MYSTERIES has 9 letters: 3 vowels and 6 consonants, worth 14 points before any board bonuses.
9-letter words 1
8-letter words 2
missteer10trisemes10
7-letter words 12
merises9messier9metiers9metisse9misters9reemits9remises9resites7retimes9smiters9stymies12triseme9
6-letter words 43
emesis8esters6eyries9merest8merits8meters8metier8metres8misers8misery11misset8mister8miters8mitres8reemit8reests6remise8remiss8remits8resets6resist6resite6resits6retems8reties6retime8seiser6serest6series6sirees6sister6smiter8smites8steers6steres6stimes8stymie11system11timers8tmeses8tmesis8tressy9yester9
5-letter words 74
emery10emirs7emits7erses5ester5eyers8eyres8eyrie8items7meets7meres7merit7messy10meter7metes7metis7metre7mires7miser7mises7missy10mists7misty10miter7mites7mitre7reest5remet7remit7reset5resit5rests5retem7retie5rimes7rises5rites5seems7seers5seise5seism7semes7semis7seres5siree5sires5sites5smite7steer5stems7stere5sties5stime7stimy10stirs5stree5styes8teems7terms7terse5tiers5timer7times7tires5trees5tress5treys8tries5trims7tyees8tyers8tyres8yeses8yetis8
4-letter words 73
eery7emes6emir6emit6erst4eses4esse4eyer7eyes7eyre7ires4isms6item6meet6mere6mess6mete6mire6mirs6miry9mise6miss6mist6mite6mity9rees4reis4rems6rest4rete4rets4rime6rims6rimy9rise4rite4ryes7seem6seer4sees4seis4seme6semi6sere4sers4sets4sims6sire4sirs4site4sits4smit6sris4stem6stey7stir4stye7teem6tees4term6tier4ties4time6tire4tree4trey7trim6tyee7tyer7tyes7tyre7yest7yeti7
3-letter words 40
eme5ems5ere3ers3ert3ess3eye6ire3ism5its3mes5met5mir5mis5mys8ree3rei3rem5res3ret3rim5rye6see3sei3ser3set3sim5sir3sis3sit3sri3sty6tee3tie3tis3try6tye6yer6yes6yet6
2-letter words 17
em4er2es2et2is2it2me4mi4ms4my7re2rs2si2ss2ti2ts2ye5
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.