Unscrambling POWERFUL gives 115 words. POWERFUL is the longest, and POWERFUL scores the most at 16 points.
No other single word uses all 8 letters of POWERFUL. POWERFUL has 8 letters: 3 vowels and 5 consonants, worth 16 points before any board bonuses.
8-letter words 1
6-letter words 9
flower12fouler9fowler12plower11purfle11reflow12upflow14woeful12wolfer12
5-letter words 12
flour8fluor8loper7loupe7lower8poler7power10prole7prowl10puler7rowel8woful11
4-letter words 42
euro4flew10floe7flop9flow10flue7fore7foul7four7fowl10froe7frow10fuel7furl7lope6lore4loup6lour4lowe7lure4orle4pelf9plew9plow9pole6pore6pouf9pour6prof9prow9pule6pure6purl6repo6role4rolf7rope6roue4roup6rule4wolf10wore7
3-letter words 37
elf6fer6feu6few9flu6foe6fop8for6fou6fro6fur6leu3lop5low6lur3ole3ope5ore3our3owe6owl6per5pew8poe5pol5pow8pro5pul5pur5ref6rep5roe3row6rue3upo5woe6wop8
2-letter words 14
ef5el2er2lo2oe2of5op4or2ow5pe4re2up4we5wo5
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.