The letters in REPLYING make 126 words of two letters or more. The longest is REPLYING at 8 letters, and the highest-scoring is REPLYING at 14 points.
No other single word uses all 8 letters of REPLYING. REPLYING has 8 letters: 2 vowels and 6 consonants, worth 14 points before any board bonuses.
8-letter words 1
7-letter words 3
preying13relying11yelping13
6-letter words 7
gripey12linger7pinery11pinger9plying12prying12ripely11
5-letter words 21
eying9genip8girly9gripe8gripy11ingle6liger6liner5liney8lingy9lying9peril7piney10plier7plyer10reign6renig6repin7reply10riley8ripen7
4-letter words 41
gien5girl5girn5glen5gley8grey8grin5grip7gyre8gyri8inly7lien4lier4line4ling5liny7lire4lyre7pein6peng7peri6pier6pile6pily9pine6ping7piny9pirn6plie6prey9prig7pyin9pyre9rein4rely7riel4rile4ring5ripe6yelp9yipe9
3-letter words 42
eng4erg4ern3gel4gen4gey7gie4gin4gip6gre4gyp9ire3leg4lei3ley6lie3lin3lip5lye6nil3nip5peg6pen5per5pie5pig6pin5ply8pry8pye8reg4rei3rep5rig4rin3rip5rye6yen6yep8yer6yin6yip8
2-letter words 11
el2en2er2in2li2ln2ne2pe4pi4re2ye5
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.