The letters in RESPONSE make 166 words of two letters or more. The longest is RESPONSE at 8 letters, and the highest-scoring is RESPONSE at 10 points.
No other single word uses all 8 letters of RESPONSE. RESPONSE has 8 letters: 3 vowels and 5 consonants, worth 10 points before any board bonuses.
8-letter words 1
7-letter words 5
6-letter words 20
eposes8eroses6opener8peones8pereon8perses8person8posers8preens8proses8reopen8repose8senors6sensor6sneers6snores6speers8spense8spores8sprees8
5-letter words 43
ernes5erose5erses5neeps7neper7noses5opens7peens7peers7penes7peons7perse7pesos7pones7pores7poser7poses7posse7preen7prees7prese7press7prone7prose7pross7renes5repos7ropes7roses5seeps7seers5senor5sense5seres5sneer5snore5sones5sores5sorns5speer7speos7spore7spree7
4-letter words 48
eons4epos6erne4erns4eros4eses4esse4neep6ness4noes4nope6nose4ones4open6opes6ores4oses4peen6peer6pees6pens6peon6peso6pone6pons6pore6pose6pree6pros6rees4repo6reps6roes4rope6rose4seen4seep6seer4sees4sene4sens4sere4sers4sone4sons4sops6sore4sorn4
3-letter words 33
ens3eon3ere3ern3ers3ess3nee3nor3nos3oes3one3ons3ope5ops5ore3ors3ose3pee5pen5per5pes5poe5pro5ree3rep5res3roe3see3sen3ser3son3sop5sos3
2-letter words 16
en2er2es2ne2no2oe2on2op4or2os2pe4ps4re2rs2so2ss2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.