The letters in SAFELY make 68 words of two letters or more. The longest is SAFELY at 6 letters, and the highest-scoring is SAFELY at 12 points.
No other single word uses all 6 letters of SAFELY. SAFELY has 6 letters: 2 vowels and 4 consonants, worth 12 points before any board bonuses.
6-letter words 1
5-letter words 8
alefs8false8flays11fleas8fleys11leafs8leafy11lyase8
4-letter words 23
alef7ales4ayes7easy7eyas7fays10feal7flay10flea7fley10lase4lays7leaf7leas4leys7lyes7lyse7safe7sale4seal4self7slay7yeas7
3-letter words 24
ale3als3aye6ays6efs6elf6els3fas6fay9fey9fly9las3lay6lea3ley6lye6sae3sal3say6sea3sel3sly6yea6yes6
2-letter words 12
ae2al2as2ay5ef5el2es2fa5la2ls2ya5ye5
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.