The letters in TOPICS make 66 words of two letters or more. The longest is OPTICS at 6 letters, and the highest-scoring is OPTICS at 10 points.
TOPICS is an anagram of OPTICS and PICOTS, using all 6 letters. TOPICS has 6 letters: 2 vowels and 4 consonants, worth 10 points before any board bonuses.
Anagrams of TOPICS 2
optics10picots10
6-letter words 3
5-letter words 7
optic9picot9pisco9posit7stoic7topic9topis7
4-letter words 21
cist6cops8cost6cots6opts6otic6pics8piso6pits6pois6post6pots6scop8scot6spit6spot6stop6tics6tips6topi6tops6
3-letter words 22
cis5cop7cos5cot5its3ops5opt5pic7pis5pit5poi5pot5psi5sic5sip5sit3sop5sot3tic5tip5tis3top5
2-letter words 13
cs4is2it2oi2op4os2pi4ps4si2so2ti2to2ts2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.